In vitro antifungal activity of Zataria multiflora essential oil, fluconazole and ciclopirox olamine against nonalbicans Candida species isolated from recurrent vulvovaginal candidiasis

Authors

  • Alireza Farasat Young Researchers & Elite Club, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
  • Azar Sabokbar Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran.
  • Farideh Zaini Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • Mahin Safara Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • Mahmoud Mahmoudi Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
  • Mohammad Ali Esfandiary Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • Mohammad Ghahri Department of Biological Sciences, College of Sciences, Imam Hussein University, Tehran, Iran.
  • Parivash Kordbacheh Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
  • Sanaz Abbasi Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran.
  • Shahram Mahmoudi Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Abstract:

The aim of the present study was to investigate the antifungal activity of Zatariamultiflora essential oil, fluconazole and ciclopirox olamine against 44 non-albicansCandida isolates from patients with recurrent vulvovaginal candidiasis. A set of C.glabrata (29 strains), C. krusei (3 stains) and C. patapsilosis (2 strains) were studiedusing Clinical and Laboratory Standards Institute (CLSI) broth macrodilution method.The results revealed that 33 isolates were resistant (MIC=64 μg/ml), 4 isolates weresusceptible (MIC≤ 8 μg/ml) and 7 isolates had dose-dependent susceptibility (MIC= 16,32 μg/ml) to fluconazole, respectively. With regard to fluconazole, high resistance ratewas observed in C .glabrata and C. krusei. However, ciclopirox olamine was found toinhibit the growth of all non-albicans Candida species (MIC≤8 μg/ml). In this study,favorable antifungal activity against non-albicans Candida species was obtained by Z.multiflora despite having a wide range of MICs (34875-139500 μg/ml). The resultsindicated that ciclopirox olamine and Z. multiflora might be promising in the treatment ofrecurrent vulvovaginal candidiasis.

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Journal title

volume 2  issue 1

pages  3- 8

publication date 2015-03-01

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